Brief Communication: Featured Article: Histone H2A mono-ubiquitination and cellular transformation are inversely related in N-nitrosodiethylamine-induced hepatocellular carcinoma
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منابع مشابه
Exploring the Protective Effects of Abrus precatorius in HepG2 and N-Nitrosodiethylamine-Induced Hepatocellular Carcinoma in Swiss Albino Rats
This study was designed to explore the protective effects of Abrus precatorius L. (Leguminosae) (AP) in HepG2 cells and N-nitrosodiethylamine (NDEA) induced hepatocellular carcinoma in Swiss albino rats. The effects of aqueous/ethanolic (50%) extract of AP on hepatic markers, haematological and histopathological parameters, and antioxidant enzymes were evaluated in NDEA ...
متن کاملexploring the protective effects of abrus precatorius in hepg2 and n-nitrosodiethylamine-induced hepatocellular carcinoma in swiss albino rats
this study was designed to explore the protective effects of abrus precatorius l. (leguminosae) (ap) in hepg2 cells and n-nitrosodiethylamine (ndea) induced hepatocellular carcinoma in swiss albino rats. the effects of aqueous/ethanolic (50%) extract of ap on hepatic markers, haematological and histopathological parameters, and antioxidant enzymes were evaluated in ndea (200 mg/kg and ccl4, 3 m...
متن کاملGender Disparity of N-nitrosodiethylamine Induced Hepatocellular Carcinoma in Wistar Albino Rats
Cancer is particularly alarming in developing countries like India where life expectancy is increasing rapidly. Over the past 25 years the incidence and mortality rates of Hepatocellular carcinoma (HCC) are expected to double over the next 10–20 years.HCC is a transformation process of normal liver cell into a cancerous cell which involves initiation, promotion and progression stages.HCC was in...
متن کاملPrognostic molecular markers in hepatocellular carcinoma (Review article
Hepatocellular carcinoma (HCC) is the 5th commonest malignancy worldwide and is the third most common cause of cancer-related death. The prevalence is different in the world. The ability to predict patients at higher risk of recurrence and with a poor prognosis would help to guide surgical and chemotherapeutic treatment according to individual risk. As understanding of hepatocarcinogenesi...
متن کاملFeatured Article p16 Hypermethylation Is Associated with Hepatitis Virus Infection, Age, and Gender in Hepatocellular Carcinoma
Purpose: The tumor suppressor gene p16 is mainly inactivated by an epigenetic change involving promoter hypermethylation in hepatocarcinogenesis. The possible clinical impact of p16 methylation and the potential risk factors for this epigenetic alteration have not been thoroughly investigated. Experimental Design: We studied the methylation status and mRNA and protein expression of p16 in 50 he...
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ژورنال
عنوان ژورنال: Experimental Biology and Medicine
سال: 2016
ISSN: 1535-3702,1535-3699
DOI: 10.1177/1535370216649262